Description
SKIN-COLIN (3x5ml)
SKIN-COLIN (3x5ml) Hyaluronic Acid & Choline Mesotherapy Solution for Skin Revitalization
SKIN-COLIN (3x5ml) is a Class III medical device (CE-marked, issued by the Istituto Superiore di Sanità) formulated as a filling and modeling solution for the dermal matrix, combining low-molecular-weight hyaluronic acid fragments with choline, amino acids, and a phosphate buffer system. Designed for the “Skin Improve” technique, SKIN-COLIN is used by aesthetic practitioners to optimize skin physiology, restore firmness, and counteract the visible effects of aging and photo-damage on the face, neck, décolleté, and hands.
What Is SKIN-COLIN (3x5ml)?
SKIN-COLIN is built around a scientifically supported combination of ingredients designed to work at the cellular level rather than simply adding volume. Its low-molecular-weight hyaluronic acid fragments (20–38 monomers) are specifically sized to activate CD44 receptors on fibroblasts, triggering the skin’s own regenerative processes, while choline — a precursor to cutaneous acetylcholine — supports the skin’s cholinergic system and helps optimize corneocyte differentiation for stronger UV damage prevention. Clinical research on HA and choline mesotherapy has demonstrated meaningful improvement in skin quality scores over a treatment course, supporting its use as an evidence-based option for facial skin aging.
Pack Details of SKIN-COLIN (3x5ml)
- 3 vials x 5ml per box
- Sterile, single-use solution
- Administered via mesotherapy/intradermal injection technique
- Class III Medical Device, CE-marked
Key Ingredients
- Hyaluronic Acid Fragments (20–38 monomers) – low-molecular-weight fragments that activate fibroblast CD44 receptors to stimulate matrix renewal
- Amino Acids – precursors for the synthesis of collagen, elastin, and glycosaminoglycans
- Phosphate Buffer System – helps maintain the sol state of the colloidal solution, supporting efficient metabolic exchange within the dermal matrix
- Choline – a precursor of cutaneous acetylcholine that supports the skin’s cholinergic system, muscle tone, and helps protect against UV-induced damage
How SKIN-COLIN Works
When injected intradermally, SKIN-COLIN activates fibroblast CD44 receptors, prompting the cells to build new collagen, elastin, and glycosaminoglycans in the surrounding tissue. Its phosphate buffer system helps neutralize matrix acidity, keeping the colloidal solution in an optimal state for metabolic exchange between cells. Meanwhile, its choline content supports the skin’s natural cholinergic activity — contributing to improved muscle tone and helping shield the skin from photo-induced aging.
Benefits of SKIN-COLIN
- Stimulates fibroblast activity for natural collagen, elastin, and glycosaminoglycan production
- Supports improved skin firmness, tone, and overall skin quality
- Helps protect against photo-aging and UV-related skin damage
- Optimizes the dermal matrix environment for better nutrient and metabolic exchange
- Supports muscle tone via choline’s role in cutaneous acetylcholine production
- Suitable for multiple treatment zones: face, neck, décolleté, and hands
Recommended Treatment Protocol
- Face: one session every 15–30 days, used alone or in combination with other treatments
- Neck and décolleté: typically administered in a series of weekly sessions, following standard mesotherapy dosing
- Injected into the dermis according to classic mesotherapy technique, distributing the solution evenly across the treatment area
Who Is It For?
SKIN-COLIN is well suited for patients looking to:
- Improve overall skin quality and firmness
- Address early signs of facial, neck, or décolleté aging
- Support skin recovery from photo-induced damage
- Combine biorevitalization with a muscle-tone-supporting ingredient not found in standard HA-only boosters
Safety Considerations
SKIN-COLIN is intended strictly for administration by trained and certified medical or aesthetic professionals using standard mesotherapy injection technique. As with other injectable dermal treatments, transient redness, swelling, or minor bruising at injection sites may occur. A patient consultation and suitability assessment is recommended prior to treatment.
Order SKIN-COLIN 3 x 5ml today and offer your patients a clinically supported mesotherapy solution that revitalizes skin quality from within the dermal matrix.
For use by licensed and trained medical and aesthetic professionals only.

