Description
Synvisc One Hylan G-F 20 3x2ml – 3 x 2ml Intra-Articular Injection
Synvisc One Hylan G-F 20 3x2ml Cross-Linked Hyaluronan Viscosupplement for Knee Osteoarthritis Pain Relief
Product Overview of Synvisc One Hylan G-F 20 3x2ml
Synvisc One Hylan G-F 20 3x2ml is an elastoviscous, high molecular weight injectable fluid manufactured by Sanofi Genzyme, containing hylan A and hylan B polymers derived from purified hyaluronan (sodium hyaluronate). Indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have not adequately responded to conservative nonpharmacologic therapy and simple analgesics such as acetaminophen, Synvisc works by supplementing the knee’s natural joint fluid, helping to lubricate and cushion the joint.
Supplied as three individual 2ml pre-filled syringes (16mg hylan polymer per syringe, 48mg total), Synvisc is administered as a course of three intra-articular injections, typically given at weekly intervals.
Key Features of Synvisc One Hylan G-F 20 3x2ml
- Volume: 3 x 2ml pre-filled syringes (6ml / 48mg total hylan polymer)
- Manufacturer: Sanofi Genzyme
- Active Ingredient: Hylan G-F 20 — a chemically cross-linked derivative of hyaluronan
- Source: Purified from hyaluronan extracted from chicken combs
- Molecular Weight: Hylan A averages approximately 6,000,000 Daltons
- Sterility: Sterile, non-pyrogenic contents
- Administration: Intra-articular knee injection, once weekly for 3 weeks
How Synvisc One Hylan G-F 20 3x2ml Works
Hyaluronan is a naturally occurring substance found in high concentrations within the joints, where it acts as a lubricant and shock absorber within the synovial fluid, allowing the knee joint to move smoothly. In osteoarthritis, the quality and concentration of this natural hyaluronan can decline, contributing to pain and reduced joint function.
Synvisc’s hylan G-F 20 is unique in that its hyaluronan is chemically cross-linked, giving it an elastoviscous quality that closely mimics and supplements the joint’s own natural fluid. Injected directly into the knee joint over a course of three weekly injections, it works to restore the joint’s natural lubrication and cushioning properties, helping to reduce pain associated with knee osteoarthritis.
Benefits
- Relieves pain associated with knee osteoarthritis
- Supplements and restores the joint’s natural lubricating fluid
- Cushions and protects the knee joint during movement
- Non-surgical option for patients who haven’t responded to standard analgesics
- Well-established treatment with decades of clinical use
- May be considered for repeat treatment based on physician assessment of response and safety
Indications
Synvisc is indicated for:
- Pain relief in knee osteoarthritis
- Patients who have failed to respond adequately to conservative, nonpharmacologic therapy
- Patients who have not achieved sufficient relief with simple analgesics such as acetaminophen
Administration
Synvisc is administered as three separate 2ml intra-articular injections into the knee, typically given at weekly intervals, using strict aseptic technique. Prior to each injection, any joint effusion or excess synovial fluid should be removed via the same needle, though not the same syringe used for injection.
Why Choose Synvisc?
- Established viscosupplement: A long-standing, clinically studied hyaluronan-based treatment for knee OA
- Trusted manufacturer: Produced by Sanofi Genzyme, a globally recognized pharmaceutical company
- Structured treatment course: The three-injection regimen allows for gradual, monitored symptom relief
- Non-surgical approach: An alternative for patients who have exhausted standard analgesic options
- Physician-guided repeat treatment: Additional courses can be considered based on ongoing assessment of pain and function
Important Usage Notes
Synvisc is intended for administration by a qualified physician or licensed practitioner using strict aseptic technique, injected directly into the knee joint. It should not be used in patients with known hypersensitivity to hyaluronan preparations. It should not be injected into joints with a skin condition or infection in or near the injection site. Product information is provided for professional and patient reference only and is not intended to replace medical advice from a licensed healthcare provider.
